Cycle of Illness: Immune System (Part III)
- Donna Muth Franklin
- 6 days ago
- 5 min read
(Slides below)
Imagine this.
You spend years going from doctor to doctor…lab after lab…test after test…
And you keep hearing the same thing:
“On paper, you’re perfectly healthy.”
Meanwhile:
your skin is breaking out in rashes or lesions
your hair is falling out
you’re exhausted or wired
your weight is changing
your mood feels unstable
your body hurts
your tolerance is shrinking
You know something is wrong — but the medical system can’t see it yet.
That’s the gap.
Understanding how these systems work together allows us — and doctors — to catch things early, before they become serious conditions.
People are suffering and it doesn't have to be this way.
What if I told we CAN change the way we treat chronic illness? Even stop it early...at the first sign of symptoms or even sooner?
Because we can.....
We could be proactive, not reactive — instead of waiting until it’s already too late.

Why this changes everything
When you understand how systems interact, it changes the nature of treatment entirely.
No more piling medication on top of medication to manage side effects caused by other medications.
No more band-aid fixes.
Instead, we support the systems that are under strain — the biochemistry, the organs, the mechanics of the body — and let the body do what it’s designed to do. HEAL.
A lot can be fixed before it ever becomes a problem. And even when it has become one — healing is completely possible.
How I came to see this
I want to be very clear about something.

Most doctors aren’t failing patients on purpose. They’re working inside a system that’s rigid, compartmentalized, and heavily boxed in by protocols, billing codes, and red tape. (and don't get me started on the insurance companies and how they maximize their profits, and share holders - at your expense)
They’re trained to look for disease after it declares itself —after labs are clearly abnormal, after damage is measurable, after patterns fit a recognized box.
That doesn’t make them bad doctors. It makes them doctors inside a system that isn’t built for early dysfunction or complex chronic illness. Lets face it, they're just as unhappy with the system as you are. At this point, current systems in place are about to implode.
Medicine should be practiced and available to all - regardless of age, gender, race, or financial portfolio. Its your God given right.
I’ve had physicians review my work and ask:
“How the H.E. double hockey sticks did you figure all of this out? Keep going.”

The answer is simple.
I didn’t have the luxury of staying inside one specialty, one system, or one textbook.
I live this reality every single day.
Everything I teach in these slide shows is something I’ve personally experienced, tracked, and had to piece together the hard way — across systems that doctors rarely catch.
You can go to school.
You can read the books, you can pass the exams.
You can see thousands of patients.
But nothing prepares you for what it’s like to live in a body that’s clearly struggling while being told everything is “normal” — because the system isn’t designed to see early breakdown, compensation, or overlapping dysfunction.
Doctors are expected to practice within tight lanes. Patients don’t get that luxury.
And when patients try to explain what they’re experiencing — especially when labs aren’t screaming yet — they’re often dismissed, not because they’re wrong, but because the system doesn’t have a place to put them.
That gap is where people suffer.
What I’ve done with the Cycle of Illness is step outside those artificial lanes and look at the body the way it actually functions — as an integrated system, not a collection of isolated parts that modern medicine likes to put them in.
This isn’t about blaming clinicians. It's about recognizing that the framework itself is outdated - and even harming patients.
And until we change how we see chronic illness, we’ll keep treating it too late, and with methods that dont actually heal us - but hijack, stimulate, or suppress other systems and biochemicals that result in even worsening metabolic issues and degradation of all the systems. We dont wan't Band-aid fixes. We want actual healing. And by golly, if we want to do the hard work to heal - we should be allowed too, and be supported by the medical systems currently in place.
WE HAVE TO CHANGE THE WAY WE THINK ABOUT MEDICINE.
Let go of which does not serve us, and replace it with something that does in the most harmonic ways that works with our bodies and the world around us. Physically, Mentally, and Spiritually.

The body is not compartmentalized
We are a big, beautiful engineering system. Plumbing. Electrical systems. Motor functions. Communication networks.
Just like the rockets in the space program at Nasa, our bodies have redundancies built in for survival.
When one system starts to fail, others compensate (this affects metabolics first). They pick up the slack. They reroute.
But compensation has a cost.
And when enough systems are strained long enough, symptoms appear — not randomly, but predictably.
Part 3: The Microbiome and System-Wide Impact
In the final part of the Immune System series, we walk through how the microbiome influences nearly every major system in the body, how it ties to the cycle of illness and where its integrated — and how all of them work together to drive either health or illness.
This isn’t theory. Its mechanics.

In these slides, we cover:
Digestive System
Carbohydrates
Proteins
Lipids, vitamins, and immune signaling
Salicylates and oxalates
Cachexia (weight loss and muscle wasting)
Cachexia and mast cells
Detox pathways
Mitochondrial Health
Immune System
Nervous System
Gut–brain access
HPA axis
Endocrine System
Metabolism and adipose tissue
Energy metabolism
Blood sugar control
Growth and development
Sex hormones
Fertility and reproduction
Sleep cycles
Mood regulation
Bone health
Hydration
Blood pressure
Neuroendocrine-immune axis
and how it differs from the neuroimmune axis
Adrenal hormones
Catecholamines
Aldosterone
Cortisol
DHEA
Norepinephrine
The Three Axis of the Endocrine System
HPT (Hypothalamus–Pituitary–Thyroid)
HPG (Hypothalamus–Pituitary–Gonadal)
HPA (Hypothalamus–Pituitary–Adrenal)
Dysbiosis/Dysregulation of the Endocrine System
Microbiome and Hormones
Microbiome and Estrogen
Microbiome and Thyroid
Microbiome and Blood Sugar (gluconeogenesis)
Microbiome and Methylation
Biopterin (BH4) production (MTHFR 1298C)
Folate receptor function (MTHFR 677T)
Microbiome and Inflammation
Microbiome and Cardiac Health
Microbiome and Food Allergies
Microbiome and Mast Cells
The point of all of this
Every system in the body is tied together.

Medicine is compartmentalized. The human body is not.
Throughout the Cycle of Illness series, I’ve been showing you how everything connects — so you can understand what’s driving your health, know what your weaknesses are so you can manage them.
EVERY. SINGLE. SYMPTOM. ties back to the Cycle of Illness.
EVERY. LAST. ONE.
When you understand how the cycles work, how the systems talk to each other, and where the feedback loops break — you don’t just manage illness.
You intervene earlier
You heal more intelligently.
And you understand more than current medicine allows itself to see. It'll change the way we see health and how medicine currently operates. You'll know what you can/can not tolerate, and help compensate if needed, and we can make medicine, treatments, foods, supplements etc... SAFER for each patient.
And it is MY HOPE, that we can change medicine for chronic illness patients and give them hope, health, peace of mind, happiness.
Love and Light,
Happy Healing.
.jpg)











Comments