PART OF THE CYCLE OF ILLNESS SERIES - IMMUNE SYSTEM PT3- HOW MICROBIOME AFFECTS OTHER SYSTEMS THESE ARE THE SLIDES IN THE VIDEOS. The microbiome and mast cells have a complex, bidirectional relationship, particularly in the gut and skin. Mast cells, immune cells involved in inflammation and allergy, interact with the microbiome through pattern recognition receptors like TLRs, influencing both immune responses and the composition of the microbiota. This interaction is crucial